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Uncertain: What Does My Result Mean?

Genetic Variant of Uncertain Significance: Overview

If your test result is "Genetic Variant of Uncertain Significance":

  • A change was detected in either your BRCA1 and BRCA2 gene but it is not known if this change is linked to cancer
  • This change is called a "genetic variant of uncertain significance"
  • Ongoing efforts to gather information about genetic variants of uncertain significance, such as the one identified in your test, will continue
  • If new information becomes available about your variant, it will be sent to the doctor who ordered your test


More about your test result


Your Cancer Risks

  • Your cancer risks should be estimated based on your family and personal history of cancer
  • Your doctor can help you understand these risks
  • It is still possible that your cancer risks could be above average due to:
  • Other non-hereditary factors, such as your environment
  • Another hereditary cancer syndrome that this test does not cover
  • A mutation in BRCA1 or BRCA2 that current technology cannot detect


On to "Uncertain: What should I do now?"

"Genetic testing helped me...do everything in my power to fight the high risk of cancer that runs in my family."

- Cathy

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